Educational dose math only — not medical advice, not a product recommendation, and not a pass/fail on whether a supplement will work for you.
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Trial reference

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Active dose is EPA + DHA on the Supplement Facts panel — not total fish oil weight. This range is the span of doses pooled across 68 RCTs and 32 meta-analyses; neither review identifies a single threshold dose, and the CRP effect weakened above BMI 30.

Educational only — not medical advice. Disclaimer.

NIH DSLD market slice

Median0.6 g
Products7,305
Below76%

Bulk CSV dump 16 January 2026 · label entries through 2025. Disclosed amounts only — proprietary blends without gram weights excluded.

Trial floors

Primary

OTC inflammatory-marker meta-analyses (EPA+DHA) · 1–2 g (medium evidence) · Benefit shown — Active dose is EPA + DHA on the Supplement Facts panel — not total fish oil weight. This range is the span of doses pooled across 68 RCTs and 32 meta-analyses; neither review identifies a single threshold dose, and the CRP effect weakened above BMI 30.

Other floors

  • EPA dose-finding in inflammatory depression · 4 g over 12 weeks (limited evidence) · Primary endpoint missed — EPA-only, in adults with major depression plus BMI over 25 and hs-CRP at or above 3 mg/L. Response was 64% vs 40% on placebo (Cohen d = 0.53) but not statistically significant, and the prespecified IL-6 and TNF endpoints were missed. A dose-finding signal in a narrow phenotype, not an established dose.

  • REDUCE-IT (prescription icosapent ethyl) · 4 g (high evidence) · Benefit shown — Prescription purified EPA — not comparable to a standard fish oil capsule.

Label reading notes

  • Read EPA and DHA separately on the Supplement Facts panel. Total fish oil grams or "1000 mg fish oil" is not the active dose.
  • Oxidation matters. Look for TOTOX, peroxide value, or third-party freshness testing; rancid oil wastes the milligrams.
  • Mood and inflammation trials point at EPA-heavy preparations in specific phenotypes. A 1:1 EPA:DHA blend at 1 g total often under-delivers EPA relative to the dose-finding work.