Documented concern based on cited evidence — not a personalized safety check, not medical advice, and not a decision to combine or avoid. That decision belongs with your prescriber.
Significant interaction — talk to your prescriber before combining
Significant documented interaction. Talk to your prescriber before combining these two.
Mechanism and evidence
Grapefruit juice blocks intestinal CYP3A4 and raises simvastatin and lovastatin exposure several-fold, the best-documented food-drug interaction in this class. The direct interaction evidence is almost entirely from grapefruit juice; bergamot extracts vary in composition.
Evidence tier: review
The tier names the strongest cited study design. Some anchors studied the supplement on its own, or a related drug in the same class — in those pairs the grade rests on that evidence plus established pharmacology, as agreed with our medical reviewer.
What to discuss with your prescriber
- Avoid grapefruit and bergamot products on simvastatin or lovastatin unless your doctor says otherwise.
- This is a daily-intake problem, not just an occasional one.