Documented concern based on cited evidence — not a personalized safety check, not medical advice, and not a decision to combine or avoid. That decision belongs with your prescriber.
Significant interaction — talk to your prescriber before combining
Significant documented interaction. Talk to your prescriber before combining these two.
Mechanism and evidence
Spironolactone is potassium-sparing by design; adding potassium on top is the textbook hyperkalemia setup.
Evidence tier: pharmacology-standard
No single PMID anchors this pair: the grading rests on established pharmacology (label practice and clinical standard) as agreed with the reviewer.
What to discuss with your prescriber
- Potassium with spironolactone only if explicitly prescribed.
- Never self-start potassium tablets on this drug.