Educational reference of documented concerns — not a personalized safety check and not a clearance to combine. Confirm with your prescriber or pharmacist.
Reviewed supplements
- ModerateOral contraceptives (combined pill)St John's wort (Hypericum perforatum) Hyperforin induces CYP3A4 and the P-glycoprotein transporter, which can speed the clearance of contraceptive steroid hormones. 2 PMIDsverified 2026-09-12
- CautionOral contraceptives (combined pill)Berberine Berberine inhibits CYP3A4 in vitro, the enzyme that clears ethinyl estradiol. 1 PMIDverified 2026-09-19
Not in this list
A supplement missing from this list has not been reviewed against Oral contraceptives (combined pill) on this site. That is not a statement that combining it is safe.