Documented concern based on cited evidence — not a personalized safety check, not medical advice, and not a decision to combine or avoid. That decision belongs with your prescriber.
Documented concern — monitor and disclose
Clinically relevant documented concern. Disclose the supplement to your clinician and keep monitoring in place.
Mechanism and evidence
Nitrates donate NO directly; adding an NO precursor can extend and amplify vasodilation. Citrulline can lower blood pressure on its own, so the combination is not automatically safe even though it is not a formal contraindication like PDE5 inhibitors with nitrates.
Evidence tier: pharmacology-standard
No single PMID anchors this pair: the grading rests on established pharmacology (label practice and clinical standard) as agreed with the reviewer.
What to discuss with your prescriber
- Do not add citrulline while on nitroglycerin or isosorbide without your cardiologist.
- Blood pressure monitoring during use was the reviewer requirement.
← All reviewed pairs for Nitrates (nitroglycerin, isosorbide mono/dinitrate)