Educational reference of documented concerns — not a personalized safety check and not a clearance to combine. Confirm with your prescriber or pharmacist.
Reviewed supplements
- ModerateMetforminBerberine Both improve insulin sensitivity and lower glucose; meta-analyses show each works alone, and together the glucose-lowering can add up, especially with other diabetes drugs in the mix. 2 PMIDsverified 2026-08-18
- CautionMetforminPanax ginseng (Korean red ginseng) Postprandial glucose effects of ginseng are small and inconsistent across preparations; with metformin alone the added hypoglycemia risk is low but not zero. 1 PMIDverified 2026-08-18
Not in this list
A supplement missing from this list has not been reviewed against Metformin on this site. That is not a statement that combining it is safe.