Educational reference of documented concerns — not a personalized safety check and not a clearance to combine. Confirm with your prescriber or pharmacist.
Reviewed supplements
- ModerateGLP-1 receptor agonists (semaglutide, tirzepatide, liraglutide)Berberine Both lower blood glucose through different pathways: GLP-1 agonists via the incretin signal and appetite, berberine via insulin sensitivity and AMPK. 1 PMIDverified 2026-09-05
- ModerateGLP-1 receptor agonists (semaglutide, tirzepatide, liraglutide)Oral contraceptives (combined pill) GLP-1 agonists slow gastric emptying, which can lower and delay the peak of pill hormones. 3 PMIDsverified 2026-09-19
- CautionGLP-1 receptor agonists (semaglutide, tirzepatide, liraglutide)Chromium picolinate (200-1000 mcg/day) Chromium may modestly improve insulin sensitivity; on top of a GLP-1 agonist a small additional glucose-lowering effect is theoretically possible. 1 PMIDverified 2026-08-18
Not in this list
A supplement missing from this list has not been reviewed against GLP-1 receptor agonists (semaglutide, tirzepatide, liraglutide) on this site. That is not a statement that combining it is safe.