Documented concern based on cited evidence — not a personalized safety check, not medical advice, and not a decision to combine or avoid. That decision belongs with your prescriber.
Significant interaction — talk to your prescriber before combining
Significant documented interaction. Talk to your prescriber before combining these two.
Mechanism and evidence
Felodipine and nifedipine are CYP3A4 substrates with documented grapefruit exposure increases; pharmacokinetic modeling puts them among the most affected drugs. The direct interaction evidence is almost entirely from grapefruit juice; bergamot extracts vary in composition.
Evidence tier: pk-model
The tier names the strongest cited study design. Some anchors studied the supplement on its own, or a related drug in the same class — in those pairs the grade rests on that evidence plus established pharmacology, as agreed with our medical reviewer.
What to discuss with your prescriber
- Avoid grapefruit juice and bergamot on felodipine or nifedipine.
- Excess low blood pressure or ankle swelling deserves a call.