Documented concern based on cited evidence — not a personalized safety check, not medical advice, and not a decision to combine or avoid. That decision belongs with your prescriber.
Documented concern — monitor and disclose
Clinically relevant documented concern. Disclose the supplement to your clinician and keep monitoring in place.
Mechanism and evidence
Atorvastatin is CYP3A4-dependent but less so than simvastatin; grapefruit raises levels to a smaller degree, so the concern is real but graded lower. The direct interaction evidence is almost entirely from grapefruit juice; bergamot extracts vary in composition.
Evidence tier: review
The tier names the strongest cited study design. Some anchors studied the supplement on its own, or a related drug in the same class — in those pairs the grade rests on that evidence plus established pharmacology, as agreed with our medical reviewer.
What to discuss with your prescriber
- Limit grapefruit intake on atorvastatin and mention it at review.
- Rosuvastatin and pravastatin are the lower-risk statins here.