Documented concern based on cited evidence — not a personalized safety check, not medical advice, and not a decision to combine or avoid. That decision belongs with your prescriber.
Documented concern — monitor and disclose
Clinically relevant documented concern. Disclose the supplement to your clinician and keep monitoring in place.
Mechanism and evidence
Amlodipine is CYP3A4-metabolized but slower; grapefruit interaction is measurable yet smaller than with felodipine or nifedipine. The direct interaction evidence is almost entirely from grapefruit juice; bergamot extracts vary in composition.
Evidence tier: pk-model
The tier names the strongest cited study design. Some anchors studied the supplement on its own, or a related drug in the same class — in those pairs the grade rests on that evidence plus established pharmacology, as agreed with our medical reviewer.
What to discuss with your prescriber
- Discuss grapefruit intake with your cardiologist on amlodipine.
- Report dizziness or swelling changes.