Documented concern based on cited evidence — not a personalized safety check, not medical advice, and not a decision to combine or avoid. That decision belongs with your prescriber.
Documented concern — monitor and disclose
Clinically relevant documented concern. Disclose the supplement to your clinician and keep monitoring in place.
Mechanism and evidence
Glycyrrhizin produces pseudo-hyperaldosteronism: potassium loss and blood pressure rise, directly working against what ACE inhibitors and ARBs are prescribed for.
Evidence tier: case-reports
The tier names the strongest cited study design. Some anchors studied the supplement on its own, or a related drug in the same class — in those pairs the grade rests on that evidence plus established pharmacology, as agreed with our medical reviewer.
What to discuss with your prescriber
- Avoid licorice root supplements on blood pressure medication unless your doctor approves.
- Report muscle weakness or palpitations, which can accompany low potassium.
← All reviewed pairs for ACE inhibitors or ARBs (lisinopril, enalapril, losartan, valsartan)