Educational dose math only — not medical advice, not a product recommendation, and not a pass/fail on whether a supplement will work for you.
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2 g/day of branded Magtein in adults aged 18-45 reporting unsatisfying sleep. Overall cognition improved (NIH Total Cognition Composite, p = 0.043) along with reaction time, resting heart rate and HRV. Raven's matrices did not change, and neither did objective sleep from a wearable — only self-reported sleep-related impairment.

Educational only — not medical advice. Disclaimer.

NIH DSLD market slice

Median2000 mg
Products152
Below41%

Bulk CSV dump 16 January 2026 · label entries through 2025. Disclosed amounts only — proprietary blends without gram weights excluded.

Trial floors

Primary

Cognition and sleep trial (compound weight) · 2,000 mg over 6 weeks (limited evidence) · Secondary outcomes only — 2 g/day of branded Magtein in adults aged 18-45 reporting unsatisfying sleep. Overall cognition improved (NIH Total Cognition Composite, p = 0.043) along with reaction time, resting heart rate and HRV. Raven's matrices did not change, and neither did objective sleep from a wearable — only self-reported sleep-related impairment.

Label reading notes

  • This dose is compound weight, not elemental magnesium. 2000 mg of magnesium L-threonate carries roughly 144 mg of elemental magnesium — about a third of the daily value, not a large dose.
  • Compare it against the elemental magnesium entry before deciding you are covered: a big number on a threonate label is not a big magnesium dose.
  • The trial used the branded Magtein preparation. Generic magnesium L-threonate at the same milligram count has no separate trial.
  • Cognitive endpoints were mixed — one composite met significance, one reasoning test did not, and objective sleep did not move.